What Stands out to me??? Only 1 Road Dog!!! and I would have to say Seattle might have the biggest home field advantage out of anyone this week, Atlanta playing back to back road games coming off an easy win vs Carolina, and having to fly across the country.
also only 1 Double digit spread only because Aaron Rodgers is OUT
| Date & Time | Favorite | Line | Underdog | Total |
| 12/16 8:20 ET | At San Diego | -8.5 | San Francisco | 44.5 |
| 12/19 1:00 ET | At St. Louis | -1.5 | Kansas City | 43 |
| 12/19 1:00 ET | At Tennessee | -1.5 | Houston | 47.5 |
| 12/19 1:00 ET | At Indianapolis | -5 | Jacksonville | 48.5 |
| 12/19 1:00 ET | At Carolina | -2.5 | Arizona | 38 |
| 12/19 1:00 ET | At Cincinnati | -1.5 | Cleveland | 40 |
| 12/19 1:00 ET | At Miami | -5.5 | Buffalo | 41 |
| 12/19 1:00 ET | At NY Giants | -2.5 | Philadelphia | 46 |
| 12/19 1:00 ET | At Dallas | -6 | Washington | 45 |
| 12/19 1:00 ET | At Tampa Bay | -6 | Detroit | 42 |
| 12/19 1:00 ET | At Baltimore | -2.5 | New Orleans | 43.5 |
| 12/19 4:05 ET | Atlanta | -6 | At Seattle | 45 |
| 12/19 4:15 ET | At Pittsburgh | -6 | NY Jets | 36 |
| 12/19 4:15 ET | At Oakland | -6.5 | Denver | 44 |
| 12/19 8:20 ET | At New England | -10.5 | Green Bay | 46.5 |