| Date & Time | Favorite | Line | Underdog | Total |
| 11/18 8:20 ET | At Miami | -1.5 | Chicago | 40 |
| 11/21 1:00 ET | At Pittsburgh | -7.5 | Oakland | 41.5 |
| 11/21 1:00 ET | At NY Jets | -6.5 | Houston | 45.5 |
| 11/21 1:00 ET | Baltimore | -10 | At Carolina | 37 |
| 11/21 1:00 ET | At Tennessee | -6* | Washington | 43* |
| 11/21 1:00 ET | At Dallas | -6.5 | Detroit | 46.5 |
| 11/21 1:00 ET | Green Bay | -3 | At Minnesota | 44 |
| 11/21 1:00 ET | At Cincinnati | -5.5 | Buffalo | 44 |
| 11/21 1:00 ET | At Jacksonville | -1.5 | Cleveland | 42.5 |
| 11/21 1:00 ET | At Kansas City | -8 | Arizona | 44 |
| 11/21 4:05 ET | At New Orleans | -11.5 | Seattle | 44 |
| 11/21 4:05 ET | Atlanta | -3 | At St. Louis | 43.5 |
| 11/21 4:05 ET | At San Francisco | -3 | Tampa Bay | 41.5 |
| 11/21 4:15 ET | At New England | -3 | Indianapolis | 50.5 |
| 11/21 8:20 ET | At Philadelphia | -3* | NY Giants | 48* |
Monday Night Football Line
| 11/22 8:35 ET | At San Diego | -10 | Denver | 50 |