| Date & Time | Favorite | Line | Underdog | Total |
| 10/24 1:00 ET | Pittsburgh | -3 | At Miami | 40.5 |
| 10/24 1:00 ET | At Atlanta | -3.5 | Cincinnati | 43 |
| 10/24 1:00 ET | At Kansas City | -4.5* | Jacksonville | 43.5* |
| 10/24 1:00 ET | At Tennessee | -3* | Philadelphia | 44* |
| 10/24 1:00 ET | At Chicago | -3 | Washington | 40 |
| 10/24 1:00 ET | At New Orleans | -13 | Cleveland | 43 |
| 10/24 1:00 ET | At Baltimore | -13 | Buffalo | 38.5 |
| 10/24 1:00 ET | San Francisco | -3 | At Carolina | 35.5 |
| 10/24 1:00 ET | At Tampa Bay | -3 | St. Louis | 38.5 |
| 10/24 4:05 ET | At Seattle | -5.5 | Arizona | 40.5 |
| 10/24 4:15 ET | At San Diego | -2.5 | New England | 47 |
| 10/24 4:15 ET | At Denver | -7 | Oakland | 42 |
| 10/24 8:20 ET | At Green Bay | -2.5 | Minnesota | 44.5 |
Monday Night Football Line
| 10/25 8:35 ET | At Dallas | -3 | NY Giants | 44.5 |